A new treatment approach appears to halt the spread of cancer cells into normal brain tissue in animal models. Researchers treated animals possessing an invasive tumor with a vesicle carrying a molecule called imipramine blue, followed by conventional doxorubicin chemotherapy. The tumors ceased their invasion of healthy tissue and the animals survived longer than animals treated with chemotherapy alone. “Our results show that imipramine blue stops tumor invasion into healthy tissue and enhances the efficacy of chemotherapy, which suggests that chemotherapy may be more effective when the target is stationary,” says Ravi Bellamkonda, a professor of biomedical engineering at the Georgia Institute of Technology and Emory University. “These results reveal a new strategy for treating brain cancer that could improve clinical outcomes.” The results of this work were published in the journal Science Translational Medicine. http://stm.sciencemag.org/content/4/127/127ra36.long